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W

Waardenburg Syndrome

Etiology: 
 

  • Define: rare genetic condition that affects pigmentation and hearing

  • Etiology: mutations in genes involved in the development of melanocytes + neural crest cells

  • Cause: defects in the differentiation of neural crest cells into melanocytes

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  • Description: patchy depigmentation of skin, hair, and irises; associated with deafness

Warfarin-induced skin necrosis

Etiology: 
 

Cause: warfarin decreases protein C = poor inactivation of factor Va and VIIIa = hypercoagulable state

 

Description: large, dark purple lesions

 

Locations: extremities, breasts, trunk, penis 

 

Associated with: Protein C deficiency

Waterhouse-Friderichsen Syndrome (meningococcal disease)

Etiology: 
 

Cause: most common causes are due to Meningococcus which leads to adrenal hemorrhage, fulminant sepsis and DIC

 

Description: petechial or ecchymotic 

 

Location: begin on trunk or legs

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