H

Hailey Hailey

Etiology:

Halo nevus

Etiology:

Cause: unknown, but suspected to related to autoimmune in origin and triggered by sunburn or local trauma

Description: white halo that surrounds a mole/nevus and is usually symmetrical and about 0.5–1.0 cm wide

Location: most often trunk

Hand Foot & Mouth Disease

Etiology:

Cause: Coxsackie A

Description: vesicular rash

Location: around the lips, mouth, and back of the throat

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Hand-Foot Syndrome

Etiology:

Cause: chemotherapy agents (5-FU, capecitabine)

Description: sunburnt-like hands that appears 2-3 months after starting chemotherapy where the whole sole or palm turns completely red

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Hand-Schüller-Christian Disease

Etiology:

Cause: unknown cause, but the number of Langerhans cells in the skin and other organs are triggered to increase (type of Langerhans cell histiocytosis); BRAF V600E mutation associated

Description: Pinkish crusted papules with lytic bone lesions in skull, diabetes insipidus, and exophthalmos

At risk: 2-6 yo

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Harlequin Ichthyosis

Etiology:

Define: severe genetic skin disorder characterized by thick, diamond-shaped plates of skin separated by deep cracks
Tx: oral retinoids

Hereditary Hemorrhagic Telangiectasia / Osler-Weber-Rendu

Etiology:

Cause: AD mutation (loss of function of ENG gene) causing thin-walled blood vessels, especially in the mouth and GI tract

Description: blanching lesions (telangiectasias) on skin and mucous membranes, recurrent epistaxis, skin discolorations, arteriovenous malformations, GI bleeding, hematuria

Herpes Labialis (cold sores)

Etiology:

Cause: HSV1

Description: shallow oral ulcers that rupture and dry after a few days forming a thin, yellowish crust and will completely heal

At risk: children (transmitted through contact with oral secretions)

Herpes Zoster / Shingles

Etiology:

Cause: recurrent VZV

Description: eruption of a “belt” of maculopapular

lesions with erythematous base along a single dermatome on the trunk

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Hidradenitis Suppurativa (HS) / Acne Inversa

Etiology: occlusion + rupture of follicles in folliculopilosebaceous units

Locations: axillae, groin, perineum, perianal, inframammary

At risk: puberty, women, obesity, cigarette smoking, IBD

Appearance: erythematous nodules, pustules, bridging comedones

Sx: recurrent tender nodules + abscesses that drain + scar

Tx:

mild = Hibiclens (1 min soak + then wash), Doxy, Clinda lotion, spironolactone
severe/scarring = biologic (Bimzelx, Humira)

Hirsutism

Etiology: late-onset CAH, prolactinoma, drugs (androgens, minoxidil, cyclosporine, carbamazepine)

Location: mustache or beard-liike distribution

Tx: correcting underlying hormonal imbalance (spironolactone, OCPs) + hair removing tx

Hypertrichosis

Etiology:

Description: excessive hair growth

Associate with: Porphyria cutanea tarda, anorexia nervosa, malignancy, drugs

Hypertrophic Scar

Etiology:

Cause: dysregulation of the normal healing process resulting in excessive production of collagen, elastin, proteoglycans, and extracellular matrix proteins

Description: Pink to red, slightly raised, or flat, limited to confines of wound, and usually occurs within weeks of injury

Hypohidrotic Ectodermal Dysplasia

Etiology:

Define: genetic disorder characterized by the abnormal development of ectodermal tissues, specifically the skin, hair, nails, teeth, and sweat glands
Appearance: thin, wrinkled, and dark-colored skin around the eyes