H
Hailey Hailey
Etiology:
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Halo nevus
Etiology: unknown, but suspected to related to autoimmune in origin and triggered by sunburn or local trauma
Description: white halo that surrounds a mole/nevus and is usually symmetrical and about 0.5–1.0 cm wide
Location: most often trunk
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Hand Foot & Mouth Disease
Etiology: Coxsackie A
Description: vesicular rash
Location: around the lips, mouth, and back of the throat
Hand-Foot Syndrome
Etiology: chemotherapy agents (5-FU, capecitabine)
Description: sunburnt-like hands that appears 2-3 months after starting chemotherapy where the whole sole or palm turns completely red
Hand-Schüller-Christian Disease
Etiology: unknown cause, but the number of Langerhans cells in the skin and other organs are triggered to increase (type of Langerhans cell histiocytosis); BRAF V600E mutation associated
Description: Pinkish crusted papules with lytic bone lesions in skull, diabetes insipidus, and exophthalmos
At risk: 2-6 yo
Harlequin Ichthyosis
Define: severe genetic skin disorder characterized by thick, diamond-shaped plates of skin separated by deep cracks
Tx: oral retinoids
Hereditary Hemorrhagic Telangiectasia / Osler-Weber-Rendu
Etiology: AD mutation (loss of function of ENG gene) causing thin-walled blood vessels, especially in the mouth and GI tract
Description: blanching lesions (telangiectasias) on skin and mucous membranes, recurrent epistaxis, skin discolorations, arteriovenous malformations, GI bleeding, hematuria
Herpes Labialis (cold sores)
Etiology: HSV1
Description: shallow oral ulcers that rupture and dry after a few days forming a thin, yellowish crust and will completely heal
At risk: children (transmitted through contact with oral secretions)
Herpes Zoster / Shingles
Etiology: recurrent VZV
Description: eruption of a “belt” of maculopapular lesions with erythematous base along a single dermatome on the trunk
Hidradenitis Suppurativa (HS) / Acne Inversa
Etiology: occlusion + rupture of follicles in folliculopilosebaceous units
Locations: axillae, groin, perineum, perianal, inframammary
At risk: puberty, women, obesity, cigarette smoking, IBD
Appearance: erythematous nodules, pustules, bridging comedones
Sx: recurrent tender nodules + abscesses that drain + scar
Tx:
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mild = Hibiclens (1 min soak + then wash), Doxy, Clinda lotion, spironolactone
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severe/scarring = biologic (Bimzelx, Humira)
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Hirsutism
Etiology: late-onset CAH, prolactinoma, drugs (androgens, minoxidil, cyclosporine, carbamazepine)
Location: mustache or beard-liike distribution
Tx: correcting underlying hormonal imbalance (spironolactone, OCPs) + hair removing tx
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Hypertrichosis
Description: excessive hair growth
Associated with: Porphyria cutanea tarda, anorexia nervosa, malignancy, drugs
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Hypertrophic Scar
Etiology: dysregulation of the normal healing process resulting in excessive production of collagen, elastin, proteoglycans, and extracellular matrix proteins
Description: Pink to red, slightly raised, or flat, limited to confines of wound, and usually occurs within weeks of injury
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Hypohidrotic Ectodermal Dysplasia
Define: genetic disorder characterized by the abnormal development of ectodermal tissues, specifically the skin, hair, nails, teeth, and sweat glands
Appearance: thin, wrinkled, and dark-colored skin around the eyes
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