G
Genital Herpes
Etiology:
Cause: HSV2
Description: painful, clear vesicles sitting on top of an erythematous base - “dew drops on a rose petal appearance”
Giant cell fibroblastoma
Etiology:
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Define: pediatric variant of DFSP
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Appearance:
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Histo: pseudovascular spaces, hypocellular psindle cells with myxoid background
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At risk: <5 yo
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Location: thigh, groin, trunk
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Tx: wide excision, MOHs
Giant cell tumor of tendon sheath
Etiology:
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Location: hands, digits
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Histo: multinodule oval shaped, darker in color, giant cells (chocolate chip cookies with extra chips and a ring of pink around it), hypercellular; pools of free floating mononuclear histiocytoid tumor cells that can form a halo of hemosiderin around it
Giant condyloma acuminatum (GCA) / Buschke-Löwenstein tumor
Etiology:
Cause: HPV 6,11
Description: slow-growing, cauliflower-like warty tumor with cobblestone surface
Giant Congenital Melanocytic Nevus / Bathing Trunk Nevus
Etiology:
Description: a proliferation of benign melanocytes that are present at birth or develop shortly after birth that is >20 cm
Giant Molluscum Contagiosum
Etiology:
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At risk: HIV, immunocompromised
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Appearance: dome-shaped, flesh-colored papules with a central indentation; >10-15 mm
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Location: trunk, armpits, and genital area
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Tx: cryotherapy, curettage, laser therapy, topical cantharidin, tretinoin, or podophyllotoxin
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Prog: Most cases resolve on their own within months to a couple of years
Gianotti-Crosti Syndrome / Infantile Papular Acrodermatitis
Etiology:
Cause: reaction to a systemic viral infection (URI or GI); #1 virus = EBV
Description: papules 5–10 mm in diameter and are a deep red color
Location: develops first on the thighs and buttocks, then on the outer aspects of the arms, and finally on the face
At risk: children between the ages of 6 months and 12 years
Glomus tumor / glomangioma
Etiology:
Gorlin Syndrome / Nevoid Basal Cell Carcinoma (NBCCS)
Etiology:
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Define: prone to developing multiple BCCs, often starting in adolescence or early adulthood
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Inheritance: AD
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Appearance: flesh-colored or reddish-brown spots to pearly or shiny bumps
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Cause: AD mutation to patched (PTCH) gene C9q
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Description: skin tags + skin cysts (blue nevi) on face + body with multiple basal cell carcinomas
Graft vs Host Disease
Etiology:
Cause: transplant rejection where immunocompetent T cells reject host cells with "foreign" proteins
Description: mild rash may be slightly sore or itchy and look like a minor sunburn
Granuloma Annularae
Etiology:
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Appearance: violasceous annular plaque with scale
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Sx: itchy
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Histo: surrounded by lots of mucin
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vs. tinea (no scale)
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Tx: Rinvoq, UVB, Niacinamide, Zoryve
Granuloma Inguinale / Donovanosis
Etiology:
Cause: Klebsiella granulomatis
Description: nodules that appear on genitalia or inguinal area that are painless, raised, beefy red, moist, smooth, and foul-smelling
Granulomatosis Infantiseptica
Etiology:
Cause: Listeria monocytogenes in neonates
Description: pyogenic granulomas distributed over the whole body
Grey-Turner sign
Etiology:
Cause: retroperitoneal bleeding (kidney laceration)
Description: ecchymosis on flanks